Protein Name:
Protein transport protein Sec16A
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UniprotKB/SwissProt ID: O15027 (O15027)
Gene Name:
SEC16A
Organism: Homo sapiens (Human)
Function: Acts as a molecular scaffold that plays a key role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining an ERES. Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:17005010, PubMed:17192411, PubMed:17428803, PubMed:21768384, PubMed:22355596). Mediates the recruitment of MIA3/TANGO to ERES (PubMed:28442536). Regulates both conventional (ER/Golgi-dependent) and GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane (PubMed:28067262). Positively regulates the protein stability of E3 ubiquitin-protein ligases RNF152 and RNF183 and the ER localization of RNF183 (PubMed:29300766). Acts as a RAB10 effector in the regulation of insulin-induced SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the cell membrane in adipocytes (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Endoplasmic reticulum membrane. Golgi apparatus membrane. Cytoplasm, perinuclear region. Cytoplasm, cytosol. Microsome membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of O15027
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
107 |
THARDSSQGP C EPLPGPLTQP |
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| 2 |
1293 |
DPRTYDRRYW C DAEYDAYRRE |
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| 3 |
1451 |
SPEKFSVPHV C ARFGPGGQLI |
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| 4 |
1522 |
INFAQNKAMK C LQNENLIDKE |
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| 5 |
1692 |
MSGRMPAAST C CGDEKWGDWR |
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| 6 |
1693 |
SGRMPAASTC C GDEKWGDWRP |
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| 7 |
1797 |
EYAQSLGAET C PLPSFQVFKF |
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| 8 |
1904 |
WHQDGALPQQ C PGTPSSEMEQ |
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| 9 |
46 |
NNNAAVAPTT C PLQPVTDPFA |
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| 10 |
504 |
GPAVPRHGAV C HTGAPDATLH |
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| 11 |
675 |
NMETLCAPQV C PLPLNSTTEA |
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| 12 |
718 |
PSARTQGPVK C ESPATTLWAQ |
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