Protein Name:
Cyclin-G-associated kinase
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UniprotKB/SwissProt ID: O14976 (O14976)
Gene Name:
GAK
Organism: Homo sapiens (Human)
Function: Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1 (PubMed:10625686). May play a role in clathrin-mediated endocytosis and intracellular trafficking, and in the dynamics of clathrin assembly/disassembly (PubMed:18489706)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, perinuclear region. Golgi apparatus, trans-Golgi network. Cell junction, focal adhesion. Cytoplasmic vesicle, clathrin-coated vesicle
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of O14976
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
1142 |
PPQAKPPPKA C TQPRPNYASN |
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| 2 |
156 |
DTVLKIFYQT C RAVQHMHRQK |
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| 3 |
472 |
PSRFHNRVSE C GWAARRAPHL |
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