Protein Name:
Hepatocyte growth factor-regulated tyrosine kinase substrate
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UniprotKB/SwissProt ID: O14964 (O14964)
Gene Name:
HGS
Organism: Homo sapiens (Human)
Function: Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as a sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Early endosome membrane. Endosome, multivesicular body membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of O14964
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
166 |
RAPDWVDAEE C HRCRVQFGVM |
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| 2 |
190 |
HHCRACGQIF C GKCSSKYSTI |
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| 3 |
215 |
IEKEVRVCEP C YEQLNRKAEG |
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