Protein Name:
Protein unc-13 homolog B
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UniprotKB/SwissProt ID: O14795 (O14795)
Gene Name:
UNC13B
Organism: Homo sapiens (Human)
Function: Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP) (By similarity). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity). In collaboration with UNC13A, facilitates neuronal dense core vesicles fusion as well as controls the location and efficiency of their synaptic release (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Membrane. Cell membrane. Synapse
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of O14795
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
175 |
RKPLPTAAAQ C SFEDPDSAVD |
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| 2 |
236 |
LLLQGSSRDS C NDSMQSYDLD |
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