Protein Name:
Tumor necrosis factor receptor superfamily member 10B
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UniprotKB/SwissProt ID: O14763 (O14763)
Gene Name:
TNFRSF10B
Organism: Homo sapiens (Human)
Function: Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:10549288). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Membrane
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Graphical Visualization of S-nitrosylation Sites:
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