Protein Name:
Na(+)/H(+) exchange regulatory cofactor NHE-RF1
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UniprotKB/SwissProt ID: O14745 (O14745)
Gene Name:
NHERF1
Organism: Homo sapiens (Human)
Function: Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Involved in the regulation of phosphate reabsorption in the renal proximal tubules. Involved in sperm capacitation. May participate in the regulation of the chloride and bicarbonate homeostasis in spermatozoa
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Apical cell membrane. Endomembrane system. Cell projection, filopodium. Cell projection, ruffle. Cell projection, microvillus
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of O14745
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
15 |
AAAGAPLPRL C CLEKGPNGYG |
CCHHHHCCCC C CEEEEECCCC |
2.35% |
24105792
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| 2 |
16 |
AAGAPLPRLC C LEKGPNGYGF |
CCHHHHCCCC C CEEEEECCCC |
6.96% |
24105792
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| 3 |
206 |
QDRIVEVNGV C MEGKQHGDVV |
CCHHHHCCCC C CEEEEECCCC |
1.86% |
24105792
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