Protein Name:
Acyl-coenzyme A thioesterase 8
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UniprotKB/SwissProt ID: O14734 (O14734)
Gene Name:
ACOT8
Organism: Homo sapiens (Human)
Function: Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels (PubMed:15194431, PubMed:9153233, PubMed:9299485). Displays no strong substrate specificity with respect to the carboxylic acid moiety of Acyl-CoAs (By similarity). Hydrolyzes medium length (C2 to C20) straight-chain, saturated and unsaturated acyl-CoAS but is inactive towards substrates with longer aliphatic chains (PubMed:9153233, PubMed:9299485). Moreover, it catalyzes the hydrolysis of CoA esters of bile acids, such as choloyl-CoA and chenodeoxycholoyl-CoA and competes with bile acid CoA:amino acid N-acyltransferase (BAAT) (By similarity). Is also able to hydrolyze CoA esters of dicarboxylic acids (By similarity). It is involved in the metabolic regulation of peroxisome proliferation (PubMed:15194431) (Microbial infection) May mediate Nef-induced down-regulation of CD4 cell-surface expression (PubMed:9153233)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Peroxisome matrix
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of O14734
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
302 |
WRQDGVLAVT C AQEGVIRVKP |
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