Protein Name:
Segment polarity protein dishevelled homolog DVL-1
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UniprotKB/SwissProt ID: O14640 (O14640)
Gene Name:
DVL1
Organism: Homo sapiens (Human)
Function: Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Cytoplasm, cytosol. Cytoplasmic vesicle
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of O14640
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
382 |
GALPRYGTSP C SSAVTRTSSS |
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