Protein Name:
TRAF-type zinc finger domain-containing protein 1
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UniprotKB/SwissProt ID: O14545 (O14545)
Gene Name:
TRAFD1
Organism: Homo sapiens (Human)
Function: Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3 (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization:
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of O14545
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
109 |
ILKLKEHEDY C GARTELCGNC |
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| 2 |
13 |
EFLDDQETRL C DNCKKEIPVF |
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| 3 |
135 |
VKDLKTHPEV C GREGEEKRNE |
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| 4 |
476 |
SRSTSGPRPG C QPSSPCVPKL |
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