Protein Name:
Calsequestrin-2
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UniprotKB/SwissProt ID: O09161 (O09161)
Gene Name:
Casq2
Organism: Mus musculus (Mouse)
Function: Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Sarcoplasmic reticulum lumen
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of O09161
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
53 |
KQMLKRYDLL C LYYHEPVSSD |
CCHHHHHHHH H HHHHHCCCCC |
2.74% |
21278135
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