Protein Name:
Beta-1,3-N-acetylglucosaminyltransferase manic fringe
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UniprotKB/SwissProt ID: O09008 (O09008)
Gene Name:
Mfng
Organism: Mus musculus (Mouse)
Function: Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules (PubMed:10935626). Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1 (PubMed:10935626, PubMed:28089369)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Golgi apparatus membrane
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Graphical Visualization of S-nitrosylation Sites:
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