Protein Name:
Dihydrolipoyl dehydrogenase, mitochondrial
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UniprotKB/SwissProt ID: O08749 (O08749)
Gene Name:
Dld
Organism: Mus musculus (Mouse)
Function: Lipoamide dehydrogenase is a component of the glycine cleavage system as well as an E3 component of three alpha-ketoacid dehydrogenase complexes (pyruvate-, alpha-ketoglutarate-, and branched-chain amino acid-dehydrogenase complex) (By similarity). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion (By similarity). A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A (By similarity). In monomeric form may have additional moonlighting function as serine protease (PubMed:17404228). Involved in the hyperactivation of spermatazoa during capacitation and in the spermatazoal acrosome reaction (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion matrix. Nucleus. Cell projection, cilium, flagellum. Cytoplasmic vesicle, secretory vesicle, acrosome
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of O08749
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
477 |
AALALEYGAS C EDIARVCHAH |
CCHHHHHHHH H HHCCCHHHHC |
5.59% |
21278135
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| 2 |
484 |
GASCEDIARV C HAHPTLSEAF |
CCHHHHHHHH H HHCCCHHHHC |
1.63% |
22178444
22588120
21278135
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| 3 |
69 |
KSAQLGFKTV C IEKNETLGGT |
CCHHHHHHHH H HHCCCHHHHC |
3.94% |
24895380
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| 4 |
80 |
IEKNETLGGT C LNVGCIPSKA |
CCHHHHHHHH H HHCCCHHHHC |
2.69% |
24895380
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| 5 |
85 |
TLGGTCLNVG C IPSKALLNNS |
CCHHHHHHHH H HHCCCHHHHC |
3.44% |
24895380
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