Protein Name:
A-kinase anchor protein 1, mitochondrial
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UniprotKB/SwissProt ID: O08715 (O08715)
Gene Name:
Akap1
Organism: Mus musculus (Mouse)
Function: Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A (PubMed:9065479, PubMed:9182549). Anchors them to the cytoplasmic face of the mitochondrial outer membrane or allows them to reside in the endoplasmic reticulum (PubMed:9065479, PubMed:9182549). Involved in mitochondrial-mediated antiviral innate immunity (By similarity). Promotes translocation of NDUFS1 into mitochondria to regulate mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) activity (PubMed:32072193). Under diabetic conditions, myocardial AKAP1 expression decreases which blocks the translocation of NDUFS1 from the cytosol to mitochondria (PubMed:32072193). Reduction of NDUFS1 in mitochondria decreases ATP production and increases mitochondrial ROS level, which causes mitochondrial dysfunction and cell apoptosis, respectively, thereby leading to cardiac dysfunction (PubMed:32072193)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion outer membrane. Mitochondrion. Endoplasmic reticulum. Endoplasmic reticulum. Mitochondrion outer membrane. Mitochondrion outer membrane. Mitochondrion outer membrane. Mitochondrion outer membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of O08715
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
352 |
ATQPKGKEES C VPASQETSLG |
CCCCHHHHHH H HHHHHHHHHH |
4.87% |
21278135
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