Protein Name:
Kininogen-1
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UniprotKB/SwissProt ID: O08677 (O08677)
Gene Name:
Kng1
Organism: Mus musculus (Mouse)
Function: Kininogens are inhibitors of thiol proteases. HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes. LMW-kininogen inhibits the aggregation of thrombocytes. LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting The active peptide bradykinin is a potent vasodilatator that is released from HMW-kininogen shows a variety of physiological effects: (A) influence in smooth muscle contraction, (B) induction of hypotension, (C) natriuresis and diuresis, (D) decrease in blood glucose level, (E) it is a mediator of inflammation and causes (E1) increase in vascular permeability, (E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Secreted, extracellular space
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of O08677
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
125 |
ENEFFIVTQT C KIAPSKAPIL |
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| 2 |
339 |
KESNTELAED C EIKHLGQSLD |
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| 3 |
369 |
WENKVVPTVK C QALDMTEMAR |
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