Protein Name:
Methionine aminopeptidase 2
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UniprotKB/SwissProt ID: O08663 (O08663)
Gene Name:
Metap2
Organism: Mus musculus (Mouse)
Function: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val) Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of O08663
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
135 |
PNGVFPKGQE C EYPPTQDGRT |
CCCHHHHHHC C CCCCCCCCCC |
63.74% |
21278135
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| 2 |
380 |
GKGVVHDDME C SHYMKNFDVG |
CCCHHHHHHC C CCCCCCCCCC |
37.37% |
21278135
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| 3 |
436 |
SKYLMALKNL C DLGIVDPYPP |
CCCHHHHHHC C CCCCCCCCCC |
55.34% |
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| 4 |
448 |
LGIVDPYPPL C DIKGSYTAQF |
CCCHHHHHHC C CCCCCCCCCC |
4.88% |
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| 5 |
468 |
FEHTILLRPT C KEVVSRGDDY |
CCCHHHHHHC C CCCCCCCCCC |
3.38% |
20925432
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