Protein Name:
Myc box-dependent-interacting protein 1
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UniprotKB/SwissProt ID: O08539 (O08539)
Gene Name:
Bin1
Organism: Mus musculus (Mouse)
Function: Is a key player in the control of plasma membrane curvature, and membrane shaping and remodeling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling (PubMed:12183633). Is a negative regulator of endocytosis (By similarity). Is also involved in the regulation of intracellular vesicles sorting, modulation of BACE1 trafficking and the control of amyloid-beta production (PubMed:12668730, PubMed:27179792). In neuronal circuits, endocytosis regulation may influence the internalization of PHF-tau aggregates (By similarity). May be involved in the regulation of MYC activity and the control cell proliferation (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Cytoplasm. Endosome. Cell membrane, sarcolemma, T-tubule
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of O08539
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
186 |
SLLEKAAPQW C QGKLQAHLVA |
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| 2 |
47 |
DETKDEQFEQ C VQNFNKQLTE |
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