Protein Name:
Calpain-2 catalytic subunit
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UniprotKB/SwissProt ID: O08529 (O08529)
Gene Name:
Capn2
Organism: Mus musculus (Mouse)
Function: Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226' (By similarity). Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs (PubMed:22711986)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Cell membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of O08529
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
301 |
VEWTGKWNDN C PSWNTVDPEV |
CCCCEEEEHH C HHHHCCCCCH |
2.93% |
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| 2 |
405 |
DEDEEDGERG C TFLVGLIQKH |
CCCCEEEEHH C HHHHCCCCCH |
2.81% |
20925432
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| 3 |
640 |
ALEEAGFKLP C QLHQVIVARF |
CCCCEEEEHH C HHHHCCCCCH |
11.02% |
20925432
21278135
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| 4 |
82 |
GIEWKRPTEI C ADPQFIIGGA |
CCCCEEEEHH C HHHHCCCCCH |
2.6% |
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