\
logo
  Home | Contact us | Browse | Quick Search by UniProtKB ID, Keyword, PDBID

Menu:

Latest news:

Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

Read more...


Protein Name: Hexokinase-2
UniprotKB/SwissProt ID: O08528 (O08528)

Gene Name: Hk2

Organism: Mus musculus (Mouse)

Function: Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively) (By similarity). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (By similarity). Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis (PubMed:18350175)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Mitochondrion outer membrane. Cytoplasm, cytosol

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR043129 ATPase_NBD
IPR001312 Hexokinase
IPR019807 Hexokinase_BS
IPR022673 Hexokinase_C
IPR022672 Hexokinase_N
The S-nitrosylation sites of O08528
No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 133 GTQLFDHIAE C LANFMDKLQI  CHHHHHHHHH H HHHCHHHHHH  3%
2 158 LPLGFTFSFP C HQTKLDESFL  CHHHHHHHHH H HHHCHHHHHH  3.32%
3 368 RLGLSPLQED C VATHRICQIV  CHHHHHHHHH H HHHCHHHHHH  1.9% 21278135
4 375 QEDCVATHRI C QIVSTRSASL  CHHHHHHHHH H HHHCHHHHHH  1.97% 21278135
5 386 QIVSTRSASL C AATLAAVLWR  CHHHHHHHHH H HHHCHHHHHH  1.93% 21278135
6 438 HKAVRRLVPD C DVRFLRSEDG  CHHHHHHHHH H HHHCHHHHHH  4.22% 21278135
7 517 APVKMLPTYV C ATPDGTEKGD  CHHHHHHHHH H HHHCHHHHHH  2.16% 21278135
8 606 LPLGFTFSFP C QQNSLDQSIL  CHHHHHHHHH H HHHCHHHHHH  6.48% 21278135
9 628 KWTKGFKASG C EGEDVVTLLK  CHHHHHHHHH H HHHCHHHHHH  5.86% 21278135
10 794 TKFLSQIESD C LALLQVRAIL  CHHHHHHHHH H HHHCHHHHHH  3.14% 21278135
11 813 ILRHLGLEST C DDSIIVKEVC  CHHHHHHHHH H HHHCHHHHHH  8.34% 21278135
12 834 TVVARRAAQL C GAGMAAVVDK  CHHHHHHHHH H HHHCHHHHHH  2.03% 21278135
13 909 KGAALITAVA C RIREAGQR--  CHHHHHHHHH H HHHCHHHHHH  2.74% 21278135