Protein Name:
Ubiquitin-like protein ISG15
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UniprotKB/SwissProt ID: O02741 (O02741)
Gene Name:
ISG15
Organism: Bos taurus (Bovine)
Function: Ubiquitin-like protein which plays a key role in the innate immune response to viral infection either via its conjugation to a target protein (ISGylation) or via its action as a free or unconjugated protein. ISGylation involves a cascade of enzymatic reactions involving E1, E2, and E3 enzymes which catalyze the conjugation of ISG15 to a lysine residue in the target protein. Exhibits antiviral activity towards both DNA and RNA viruses. The secreted form of ISG15 can: induce natural killer cell proliferation, augment lymphokine-activated-killer (LAK) activity, induce dendritic cell maturation, act as a chemotactic factor for neutrophils and act as a IFN-gamma-inducing cytokine playing an essential role in antimycobacterial immunity (By similarity). The secreted form acts through the integrin ITGAL/ITGB2 receptor to initiate activation of SRC family tyrosine kinases including LYN, HCK and FGR which leads to secretion of IFNG and IL10; the interaction is mediated by ITGAL (By similarity). In response to IFN-tau secreted by the conceptus, may ligate to and regulate proteins involved in the release of prostaglandin F2-alpha (PGF), and thus prevent lysis of the corpus luteum and maintain the pregnancy (PubMed:9546718)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Secreted
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of O02741
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
143 |
PLEEYGLMKG C TVFMNLRLRG |
CCCCEEEEEC C CEEEEEECCC |
2.15% |
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| 2 |
78 |
GSTVLLVVQN C ISILVRNDKG |
CCCCEEEEEC C CEEEEEECCC |
1.12% |
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