Protein Name:
Podocalyxin
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UniprotKB/SwissProt ID: O00592 (O00592)
Gene Name:
PODXL
Organism: Homo sapiens (Human)
Function: Involved in the regulation of both adhesion and cell morphology and cancer progression. Functions as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up initial epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Apical cell membrane. Cell projection, lamellipodium. Cell projection, filopodium. Cell projection, ruffle. Cell projection, microvillus. Membrane raft. Membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of O00592
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
344 |
TVAHESNWAK C EDLETQTQSE |
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| 2 |
381 |
ASDEKLISLI C RAVKATFNPA |
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