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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Neural cell adhesion molecule L1-like protein

UniprotKB/SwissProt ID: O00533 (O00533)

Gene Name: CHL1

Organism: Homo sapiens (Human)

Function: Extracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity. Both soluble and membranous forms promote neurite outgrowth of cerebellar and hippocampal neurons and suppress neuronal cell death. Plays a role in neuronal positioning of pyramidal neurons and in regulation of both the number of interneurons and the efficacy of GABAergic synapses. May play a role in regulating cell migration in nerve regeneration and cortical development. Potentiates integrin-dependent cell migration towards extracellular matrix proteins. Recruits ANK3 to the plasma membrane (By similarity)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cell membrane. Secreted, extracellular space, extracellular matrix

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013151 Immunoglobulin_dom
IPR051170 Neural/epithelial_adhesion
IPR026966 Neurofascin/L1/NrCAM_C

The S-nitrosylation sites of O00533

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 1101 ALLTLLLLTV C FVKRNRGGKY