Protein Name:
DNA-directed RNA polymerase, mitochondrial
|
UniprotKB/SwissProt ID: O00411 (O00411)
Gene Name:
POLRMT
Organism: Homo sapiens (Human)
Function: DNA-dependent RNA polymerase catalyzes the transcription of mitochondrial DNA into RNA using the four ribonucleoside triphosphates as substrates (PubMed:21278163, PubMed:33602924). Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA (PubMed:29149603). In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand (PubMed:29149603). Has DNA primase activity (PubMed:18685103, PubMed:33602924). Catalyzes the synthesis of short RNA primers that are necessary for the initiation of lagging-strand DNA synthesis from the origin of light-strand DNA replication (OriL) (PubMed:18685103, PubMed:33602924)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion
|
|
|
Graphical Visualization of S-nitrosylation Sites:
|
|
The S-nitrosylation sites of O00411
|
| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
319 |
QDQDAGTIER C LEQMSQEGLK |
|
|
|
| 2 |
535 |
ALQNHYRKYL C LLASDAEVPE |
|
|
|
| 3 |
809 |
NMDFRGRTYP C PPHFNHLGSD |
|
|
|
| 4 |
94 |
NRVDVARLPE C GSGDGSLQPP |
|
|
|
|
