Protein Name:
cGMP-dependent 3',5'-cyclic phosphodiesterase
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UniprotKB/SwissProt ID: O00408 (O00408)
Gene Name:
PDE2A
Organism: Homo sapiens (Human)
Function: cGMP-activated cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:15938621, PubMed:29392776, PubMed:9210593). Has a higher efficiency with cGMP compared to cAMP (PubMed:15938621). Plays a role in cell growth and migration (PubMed:24705027) Regulates mitochondrial cAMP levels and respiration (By similarity). Involved in the regulation of mitochondria morphology/dynamics and apoptotic cell death via local modulation of cAMP/PKA signaling in the mitochondrion, including the monitoring of local cAMP levels at the outer mitochondrial membrane and of PKA-dependent phosphorylation of DNM1L (PubMed:28463107)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Mitochondrion matrix. Mitochondrion inner membrane. Mitochondrion outer membrane. Cytoplasm. Mitochondrion
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Graphical Visualization of S-nitrosylation Sites:
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