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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Pyruvate dehydrogenase protein X component, mitochondrial

UniprotKB/SwissProt ID: O00330 (O00330)

Gene Name: PDHX

Organism: Homo sapiens (Human)

Function: Required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Mitochondrion matrix

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR003016 2-oxoA_DH_lipoyl-BS
IPR001078 2-oxoacid_DH_actylTfrase
IPR000089 Biotin_lipoyl
IPR023213 CAT-like_dom_sf
IPR045257 E2/Pdx1
IPR036625 E3-bd_dom_sf
IPR004167 PSBD
IPR011053 Single_hybrid_motif

The S-nitrosylation sites of O00330

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 307 TVPHAYATAD C DLGAVLKVRQ   
2 91 GEAVSAGDAL C EIETDKAVVT