Protein Name:
Chloride intracellular channel protein 1
|
UniprotKB/SwissProt ID: O00299 (O00299)
Gene Name:
CLIC1
Organism: Homo sapiens (Human)
Function: In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor. Reduces selenite and dehydroascorbate and may act as an antioxidant during oxidative stress response (PubMed:25581026, PubMed:37759794). Can insert into membranes and form voltage-dependent multi-ion conductive channels. Membrane insertion seems to be redox-regulated and may occur only under oxidizing conditions. Involved in regulation of the cell cycle
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Nucleus membrane. Cytoplasm. Cell membrane. Endoplasmic reticulum
|
|
|
Graphical Visualization of S-nitrosylation Sites:
|
|
The S-nitrosylation sites of O00299
|
| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
178 |
LDGNELTLAD C NLLPKLHIVQ |
CCCCCCCEEE E EEECCCCCEE |
3% |
24105792
|
| 2 |
191 |
LPKLHIVQVV C KKYRGFTIPE |
CCCCCCCEEE E EEECCCCCEE |
3.1% |
20140087
24105792
|
| 3 |
223 |
AYAREEFAST C PDDEEIELAY |
CCCCCCCEEE E EEECCCCCEE |
3.01% |
|
| 4 |
24 |
AGSDGAKIGN C PFSQRLFMVL |
CCCCCCCEEE E EEECCCCCEE |
2.8% |
24105792
|
| 5 |
59 |
KRRTETVQKL C PGGQLPFLLY |
CCCCCCCEEE E EEECCCCCEE |
3.66% |
24105792
|
| 6 |
89 |
KIEEFLEAVL C PPRYPKLAAL |
CCCCCCCEEE E EEECCCCCEE |
3.33% |
|
|
