Protein Name:
Membrane-associated progesterone receptor component 1
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UniprotKB/SwissProt ID: O00264 (O00264)
Gene Name:
PGRMC1
Organism: Homo sapiens (Human)
Function: Component of a progesterone-binding protein complex (PubMed:28396637). Binds progesterone (PubMed:25675345). Has many reported cellular functions (heme homeostasis, interaction with CYPs). Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan (By similarity). Intracellular heme chaperone. Regulates heme synthesis via interactions with FECH and acts as a heme donor for at least some hemoproteins (PubMed:27599036). Forms a ternary complex with TMEM97 receptor and low density lipid receptor/LDLR, which increases LDLR-mediated LDL lipoprotein internalization (PubMed:30443021)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Microsome membrane. Smooth endoplasmic reticulum membrane. Mitochondrion outer membrane. Secreted
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of O00264
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
129 |
RDASRGLATF C LDKEALKDEY |
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