Protein Name:
26S proteasome non-ATPase regulatory subunit 12
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UniprotKB/SwissProt ID: O00232 (O00232)
Gene Name:
PSMD12
Organism: Homo sapiens (Human)
Function: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization:
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of O00232
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
108 |
KQAVAKMVQQ C CTYVEEITDL |
CCCCCCCCCC C CEEEEEEECC |
0.75% |
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| 2 |
109 |
QAVAKMVQQC C TYVEEITDLP |
CCCCCCCCCC C CEEEEEEECC |
2.4% |
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| 3 |
193 |
VEFILEQMRL C LAVKDYIRTQ |
CCCCCCCCCC C CEEEEEEECC |
1.29% |
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| 4 |
255 |
KHYRAIYDTP C IQAESEKWQQ |
CCCCCCCCCC C CEEEEEEECC |
3.8% |
19483679
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| 5 |
31 |
SATVDQRLPE C AKLAKEGRLQ |
CCCCCCCCCC C CEEEEEEECC |
3.7% |
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