Protein Name:
Tumor necrosis factor receptor superfamily member 10A
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UniprotKB/SwissProt ID: O00220 (O00220)
Gene Name:
TNFRSF10A
Organism: Homo sapiens (Human)
Function: Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:26457518, PubMed:38532423). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis (PubMed:19090789). Promotes the activation of NF-kappa-B (PubMed:9430227)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Membrane raft. Cytoplasm, cytosol
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of O00220
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
336 |
VTVQSPGEAQ C LLGPAEAEGS |
CCCCCCEEEE C EEEEECCCCC |
4.34% |
22178444
16847314
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