UniprotKB/SwissProt ID: O00142 (O00142)
Gene Name:
TK2
Organism: Homo sapiens (Human)
Function: Phosphorylates thymidine, deoxycytidine, and deoxyuridine in the mitochondrial matrix (PubMed:11687801, PubMed:9989599). In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on TK2 and DGUOK (PubMed:9989599). Widely used as target of antiviral and chemotherapeutic agents (PubMed:9989599)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion
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