Protein Name:
Deoxyribonuclease-2-alpha
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UniprotKB/SwissProt ID: O00115 (O00115)
Gene Name:
DNASE2
Organism: Homo sapiens (Human)
Function: Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the clearance of nucleic acids generated through apoptosis, hence preventing autoinflammation (PubMed:29259162, PubMed:31775019). Necessary for proper fetal development and for definitive erythropoiesis in fetal liver and bone marrow, where it degrades nuclear DNA expelled from erythroid precursor cells (PubMed:29259162)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Lysosome
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of O00115
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
308 |
WCVSPKGPWT C VGDMNRNQGE |
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