UniprotKB/SwissProt ID: M9PF61 (M9PF61)
Gene Name:
Ar1
Organism: Drosophila melanogaster (Fruit fly)
Function: Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides, bile acids and xenobiotics substrates. Key enzyme in the polyol pathway, catalyzes reduction of glucose to sorbitol during hyperglycemia. Reduces steroids and their derivatives and prostaglandins (By similarity). Through production of prostaglandin F2alpha may regulate the activity of non-muscle myosin II in an autocrine or paracrine fashion; influences border cell and nurse cell stiffness to facilitate border cell cluster migration (PubMed:38283991). Also regulates the cell surface localization of integrins in an autocrine or paracrine fashion; influences border cell adhesion to maintain border cell cluster morphology (PubMed:38283991). In hemocytes, probably contributes to production of sugar alcohols in the hemolymph, which act as alarmins involved in gut-fat body innate immunological communication (GFIC); leads to activation of the imd/Relish signaling pathway in the fat body (PubMed:31350199)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm
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