Protein Name:
Pyruvate kinase
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UniprotKB/SwissProt ID: M0RD14 (M0RD14)
Gene Name:
Pkml1
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the final rate-limiting step of glycolysis by mediating the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival Pyruvate kinase isoform expressed in adult tissues, which replaces isoform M2 after birth. In contrast to isoform M2, has high pyruvate kinase activity by itself and does not require allosteric activation by D-fructose 1,6-bisphosphate (FBP) for activity
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization:
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of M0RD14
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
309 |
RCNRAGKPVI C ATQMLESMIK |
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| 2 |
341 |
VANAVLDGAD C IMLSGETAKG |
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| 3 |
406 |
AVGAVEASFK C CSGAIIVLTK |
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| 4 |
407 |
VGAVEASFKC C SGAIIVLTKS |
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| 5 |
457 |
HLYRGIFPVL C KDAVLDAWAE |
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| 6 |
49 |
PITARNTGII C TIGPASRSVE |
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