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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Dual specificity phosphatase 28

UniprotKB/SwissProt ID: H7C234 (H7C234)

Gene Name: DUSP28

Organism: Homo sapiens (Human)

Function: Has phosphatase activity with the synthetic substrate 6,8-difluoro-4-methylumbelliferyl phosphate (in vitro). Has almost no detectable activity with phosphotyrosine, even less activity with phosphothreonine and displays complete lack of activity with phosphoserine. The poor activity with phosphotyrosine may be due to steric hindrance by bulky amino acid sidechains that obstruct access to the active site

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR000340 Dual-sp_phosphatase_cat-dom
IPR052103 Dual_spec_Phospatases
IPR029021 Prot-tyrosine_phosphatase-like
IPR000387 Tyr_Pase_dom
IPR020422 TYR_PHOSPHATASE_DUAL_dom