UniprotKB/SwissProt ID: H0Y8X4 (H0Y8X4)
Gene Name:
DNPH1
Organism: Homo sapiens (Human)
Function: Part of a nucleotide salvage pathway that eliminates epigenetically modified 5-hydroxymethyl-dCMP (hmdCMP) in a two-step process entailing deamination to cytotoxic 5-hydroxymethyl-dUMP (hmdUMP), followed by its hydrolysis into 5-hydroxymethyluracil (hmU) and 2-deoxy-D-ribose 5-phosphate (deoxyribosephosphate). Catalyzes the second step in that pathway, the hydrolysis of the N-glycosidic bond in hmdUMP, degrading this cytotoxic nucleotide to avoid its genomic integration
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization:
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