UniprotKB/SwissProt ID: G5E829 (G5E829)
Gene Name:
Atp2b1
Organism: Mus musculus (Mouse)
Function: Catalyzes the hydrolysis of ATP coupled with the transport of calcium from the cytoplasm to the extracellular space thereby maintaining intracellular calcium homeostasis (PubMed:16956963, PubMed:22311909, PubMed:23266958, PubMed:24805951, PubMed:26392310, PubMed:28827723, PubMed:29950683). Plays a role in blood pressure regulation through regulation of intracellular calcium concentration and nitric oxide production leading to regulation of vascular smooth muscle cells vasoconstriction (PubMed:22311909, PubMed:24805951, PubMed:29950683). Positively regulates bone mineralization through absorption of calcium from the intestine (PubMed:23266958, PubMed:26392310). Plays dual roles in osteoclast differentiation and survival by regulating RANKL-induced calcium oscillations in preosteoclasts and mediating calcium extrusion in mature osteoclasts (PubMed:23266958). Regulates insulin sensitivity through calcium/calmodulin signaling pathway by regulating AKT1 activation and NOS3 activation in endothelial cells (By similarity). May play a role in synaptic transmission by modulating calcium and proton dynamics at the synaptic vesicles
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Basolateral cell membrane. Synapse. Presynaptic cell membrane. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane
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