Protein Name:
Prolow-density lipoprotein receptor-related protein 1
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UniprotKB/SwissProt ID: G3V928 (G3V928)
Gene Name:
Lrp1
Organism: Rattus norvegicus (Rat)
Function: Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells (By similarity). Required for early embryonic development (By similarity). Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. Acts as an LRPAP1 alpha-2-macroglobulin receptor. Acts as a TAU/MAPT receptor and controls the endocytosis of TAU/MAPT as well as its subsequent spread. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission. Also acts as a receptor for IGFBP3 to mediate cell growth inhibition (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Membrane, coated pit. Cell membrane. Membrane, coated pit. Golgi outpost. Cytoplasm, cytoskeleton, microtubule organizing center. Cytoplasm. Nucleus
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of G3V928
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
2518 |
GGRILQEDFT C RAMNSSCRAQ |
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| 2 |
4295 |
VNQGNQPQCR C LPGFLGDRCQ |
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| 3 |
4331 |
MAADGSRQCR C TVYFEGTRCE |
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| 4 |
4348 |
TRCEVNKCSR C LQGACVVNKQ |
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