Protein Name:
Huntingtin-interacting protein 1
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UniprotKB/SwissProt ID: G3V8Y8 (G3V8Y8)
Gene Name:
Hip1
Organism: Rattus norvegicus (Rat)
Function: Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner. Regulates presynaptic nerve terminal activity. Enhances androgen receptor (AR)-mediated transcription. May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. May play a functional role in the cell filament networks. May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasmic vesicle, clathrin-coated vesicle membrane. Nucleus
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of G3V8Y8
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
220 |
RSVSVTTAGQ C RLAPLIQVIL |
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| 2 |
613 |
LKLAGAQDSM C QQIKDQRRIL |
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| 3 |
63 |
VAVKEKHART C ILGTHHEKGA |
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