Protein Name:
Transferrin receptor protein 1
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UniprotKB/SwissProt ID: G3V0E5 (G3V0E5)
Gene Name:
TFRC
Organism: Homo sapiens (Human)
Function: Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Melanosome
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Graphical Visualization of S-nitrosylation Sites:
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