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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Histone deacetylase 2

UniprotKB/SwissProt ID: F7ENH8 (F7ENH8)

Gene Name: Hdac2

Organism: Rattus norvegicus (Rat)

Function: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR050284 HDAC_PDAC
IPR000286 His_deacetylse
IPR003084 His_deacetylse_1
IPR023801 His_deacetylse_dom
IPR037138 His_deacetylse_dom_sf
IPR023696 Ureohydrolase_dom_sf

The S-nitrosylation sites of F7ENH8

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 262 MYQPSAVVLQ C GADSLSGDRL   
2 274 ADSLSGDRLG C FNLTVKGHAK   
3 285 FNLTVKGHAK C VEVVKTFNLP   
4 417 SIRASDKRIA C DEEFSDSEDE