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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Sodium channel protein

UniprotKB/SwissProt ID: F7D6K4 (F7D6K4)

Gene Name: Scn8a

Organism: Mus musculus (Mouse)

Function: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient Pore-forming subunit of a voltage-gated sodium channel complex assuming opened or closed conformations in response to the voltage difference across membranes and through which sodium ions selectively pass along their electrochemical gradient. Contributes to neuronal excitability by regulating action potential threshold and propagation

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cell membrane. Cell projection, axon

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR005821 Ion_trans_dom
IPR000048 IQ_motif_EF-hand-BS
IPR008054 Na_channel_a8su
IPR001696 Na_channel_asu
IPR044564 Na_chnl_inactivation_gate
IPR010526 Na_trans_assoc_dom
IPR024583 Na_trans_cytopl
IPR043203 VGCC_Ca_Na
IPR027359 Volt_channel_dom_sf