Protein Name:
Ras/Rap GTPase-activating protein SynGAP
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UniprotKB/SwissProt ID: F6SEU4 (F6SEU4)
Gene Name:
Syngap1
Organism: Mus musculus (Mouse)
Function: Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR-mediated miniature excitatory postsynaptic currents. Exhibits dual GTPase-activating specificity for Ras and Rap. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Membrane. Synapse
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of F6SEU4
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
821 |
PPLARSSPAY C TSSSDITEPE |
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