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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Bifunctional TH2 protein, mitochondrial

UniprotKB/SwissProt ID: F4KFT7 (F4KFT7)

Gene Name: TH2

Organism: Arabidopsis thaliana (Mouse-ear cress)

Function: May be involved in the salvage of thiamine breakdown products (PubMed:25014715). This protein has a haloacid dehalogenase family domain fused to its TenA domain (PubMed:25014715). Phosphatase with the highest activity against thiamine monophosphate (ThMP) and, with a lower activity, against thiamine diphosphate (ThDP), flavin mononucleotide, inorganic pyrophosphate, CTP and dATP (PubMed:27677881). Has a thiamine salvage hydrolase activity, but only against 4-amino-5-aminomethyl-2-methylpyrimidine (amino-HMP) and not against N-formylamino-HMP, desthiothiamine, thiamine, ThMP, and ThDP (PubMed:27677881)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Mitochondrion. Cytoplasm. Cytoplasm

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR016084 Haem_Oase-like_multi-hlx
IPR004305 Thiaminase-2/PQQC
IPR050967 Thiamine_Salvage_TenA

The S-nitrosylation sites of F4KFT7

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 396 KADKFDYEGL C KALEQLSDFE