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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Folylpolyglutamate synthase

UniprotKB/SwissProt ID: F4K2A1 (F4K2A1)

Gene Name: FPGS1

Organism: Arabidopsis thaliana (Mouse-ear cress)

Function: Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Essential for organellar and whole-plant folate homeostasis. Required for postembryonic root development. Generates polyglutamylated folate cofactors to support C1 metabolism required for meristem maintenance and cell expansion during postembryonic root development

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Plastid, chloroplast

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR001645 Folylpolyglutamate_synth
IPR018109 Folylpolyglutamate_synth_CS
IPR023600 Folylpolyglutamate_synth_euk
IPR036565 Mur-like_cat_sf
IPR036615 Mur_ligase_C_dom_sf

The S-nitrosylation sites of F4K2A1

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 396 GAHSPESMEA C AKWFSVAVKG