Protein Name:
E3 ubiquitin-protein ligase
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UniprotKB/SwissProt ID: F1M3F2 (F1M3F2)
Gene Name:
Smurf2
Organism: Rattus norvegicus (Rat)
Function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD7 to trigger SMAD7-mediated transforming growth factor beta/TGF-beta receptor ubiquitin-dependent degradation, thereby down-regulating TGF-beta signaling. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with AIMP1. Also forms a stable complex with TGF-beta receptor-mediated phosphorylated SMAD1, SMAD2 and SMAD3, and targets SMAD1 and SMAD2 for ubiquitination and proteasome-mediated degradation. SMAD2 may recruit substrates, such as SNON, for ubiquitin-dependent degradation. Negatively regulates TGFB1-induced epithelial-mesenchymal transition and myofibroblast differentiation
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Cytoplasm. Membrane raft. Nucleus
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of F1M3F2
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
716 |
CTNNLPKAHT C FNRIDIPPYE |
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