Protein Name:
Triple functional domain protein
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UniprotKB/SwissProt ID: F1M0Z1 (F1M0Z1)
Gene Name:
Trio
Organism: Rattus norvegicus (Rat)
Function: Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases. Involved in coordinating actin remodeling, which is necessary for cell migration and growth (By similarity). Plays a key role in the regulation of neurite outgrowth and lamellipodia formation (By similarity). In developing hippocampal neurons, limits dendrite formation, without affecting the establishment of axon polarity. Once dendrites are formed, involved in the control of synaptic function by regulating the endocytosis of AMPA-selective glutamate receptors (AMPARs) at CA1 excitatory synapses (PubMed:26721934). May act as a regulator of adipogenesis (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Cell projection
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of F1M0Z1
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
1024 |
VAFYKTSEQV C SVLESLEQEY |
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| 2 |
1041 |
EQEYKREEDW C GGADKLGPNS |
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| 3 |
1991 |
TERDYVRDLG C VVEGYMALMK |
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| 4 |
2137 |
SELEKAVEVM C IVPKRCNDMM |
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| 5 |
465 |
EKYMSNVDSW C KACGEVDLPS |
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