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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Asparagine--tRNA ligase, cytoplasmic

UniprotKB/SwissProt ID: F1LPV0 (F1LPV0)

Gene Name: Nars1

Organism: Rattus norvegicus (Rat)

Function: Catalyzes the attachment of asparagine to tRNA(Asn) in a two-step reaction: asparagine is first activated by ATP to form Asn-AMP and then transferred to the acceptor end of tRNA(Asn). In addition to its essential role in protein synthesis, acts as a signaling molecule that induced migration of CCR3-expressing cells. Has an essential role in the development of the cerebral cortex, being required for proper proliferation of radial glial cells

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR004364 Aa-tRNA-synt_II
IPR006195 aa-tRNA-synth_II
IPR045864 aa-tRNA-synth_II/BPL/LPL
IPR004522 Asn-tRNA-ligase
IPR048952 AsnRS_N
IPR002312 Asp/Asn-tRNA-synth_IIb
IPR012340 NA-bd_OB-fold
IPR004365 NA-bd_OB_tRNA

The S-nitrosylation sites of F1LPV0

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 124 KNDPSLPEPA C VKISALEGYR   
2 276 FRDHFFDRGY C EVTTPTLVQT   
3 369 DLLSRLEDLV C DVVDRVLKSP   
4 448 TDTINEPILL C RFPVEIKSFY   
5 521 WYTDQRKYGT C PHGGYGLGLE