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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: 2-oxoglutarate dehydrogenase-like, mitochondrial

UniprotKB/SwissProt ID: E9Q7L0 (E9Q7L0)

Gene Name: Ogdhl

Organism: Mus musculus (Mouse)

Function: 2-oxoglutarate dehydrogenase (E1-like) component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDHC) which mediates the decarboxylation of alpha-ketoglutarate in the tricarboxylic acid cycle. The OGDHC complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) while reducing NAD(+) to NADH. The OGDHC complex is mainly active in the mitochondrion. Involved in the inhibition of cell proliferation and in apoptosis

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Mitochondrion matrix

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR032106 2-oxogl_dehyd_N
IPR011603 2oxoglutarate_DH_E1
IPR001017 DH_E1
IPR042179 KGD_C_sf
IPR031717 ODO-1/KGD_C
IPR029061 THDP-binding
IPR005475 Transketolase-like_Pyr-bd

The S-nitrosylation sites of E9Q7L0

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 513 FNKDVVVDLV C YRRRGHNEMD   
2 610 NVDGEPKSMT C PTTGIPEEML   
3 961 EKYSGAELVW C QEEHKNMGYY