Protein Name:
Ryanodine receptor 1
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UniprotKB/SwissProt ID: E9PZQ0 (E9PZQ0)
Gene Name:
Ryr1
Organism: Mus musculus (Mouse)
Function: Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytosol and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules (PubMed:18003898, PubMed:21156754, PubMed:7515481, PubMed:7621815). Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm (PubMed:18268335). Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain (PubMed:22036948). Required for normal embryonic development of muscle fibers and skeletal muscle (PubMed:7515481). Required for normal heart morphogenesis, skin development and ossification during embryogenesis (PubMed:18003898, PubMed:7515481)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Sarcoplasmic reticulum membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of E9PZQ0
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
1041 |
ATKRSNRDSL C QAVRTLLGYG |
CCCCCCCCCC C EEEEECCCCH |
2.56% |
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| 2 |
2327 |
KGYPDIGWNP C GGERYLDFLR |
CCCCCCCCCC C EEEEECCCCH |
11.19% |
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| 3 |
2364 |
VVRLLIRKPE C FGPALRGEGG |
CCCCCCCCCC C EEEEECCCCH |
6.92% |
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| 4 |
316 |
SKAHTKATSF C FRISKEKLDV |
CCCCCCCCCC C EEEEECCCCH |
1.93% |
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| 5 |
3194 |
VEKLRPALGE C LARLAAAMPV |
CCCCCCCCCC C EEEEECCCCH |
3.23% |
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| 6 |
3636 |
SKQRRRAVVA C FRMTPLYNLP |
CCCCCCCCCC C EEEEECCCCH |
1.18% |
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| 7 |
37 |
ATVLKEQLKL C LAAEGFGNRL |
CCCCCCCCCC C EEEEECCCCH |
2.02% |
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| 8 |
812 |
KFLPPPGYAP C HEAVLPRERL |
CCCCCCCCCC C EEEEECCCCH |
3.26% |
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