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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Adenylosuccinate synthetase isozyme 2

UniprotKB/SwissProt ID: D4AEP0 (D4AEP0)

Gene Name: Adss2

Organism: Rattus norvegicus (Rat)

Function: Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP Plays an important role in the de novo pathway of purine nucleotide biosynthesis

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Mitochondrion

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR018220 Adenylosuccin_syn_GTP-bd
IPR033128 Adenylosuccin_syn_Lys_AS
IPR042109 Adenylosuccinate_synth_dom1
IPR042110 Adenylosuccinate_synth_dom2
IPR042111 Adenylosuccinate_synth_dom3
IPR001114 Adenylosuccinate_synthetase
IPR027529 AdSS_2_vert
IPR027417 P-loop_NTPase

The S-nitrosylation sites of D4AEP0

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 58 DLLAQDADIV C RCQGGNNAGH