Protein Name:
Tumor necrosis factor receptor type 1-associated DEATH domain protein
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UniprotKB/SwissProt ID: D3ZZC5 (D3ZZC5)
Gene Name:
Tradd
Organism: Rattus norvegicus (Rat)
Function: Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B. The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, cytoskeleton. Nucleus
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of D3ZZC5
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
135 |
LDSWLTDEER C LNYILAQKPD |
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